A unique encapsulated micro-liver

Our main product, HepatoPearl® , has been validated as a superiour in vitro liver model for different applications from drug-induced liver injury,drug-drug interactions, chronic toxicity to metabolism of low clearance compounds.

Cyprio is continuously developing new products to definitively change liver cell-culture biology approaches towards more complex and more relevant, yet more robust, easier to handle and HTS compatible 3D cellular models.

HepatoPearls® characteristics

Easy to handle and adaptable to any bioassay, our system makes 3D Hepatocyte culture accessible to everyone.

HepatoPearls, are designed:

  • to address fundamental questions in biological research

  • as a reliable tool for drug screening assays

  • to become a novel solution for therapeutical and biomedical applications

Both predictive and convenient, the most flexible 3D-model on the market compatible with all readouts and automation systems and experiment-ready following YOUR needs:

Extended lifespan: up to 45 days with high hepatic functions

Predictive: mimics liver architecture and functions

Quality controlled: fully characterized Primary Human or Rat Hepatocyte from major suppliers

Translational: run multi-species comparisons

Experiment-ready: delivered in the industry standard micro plates of your choosing

Versatile: compatible with all readouts and automation systems

Human HepatoPearls® : Miniaturized Liver-mimicking Systems

A polarized 3D structure

Zo-1 polarization marker

Biliary canaliculi (CFDA staining)

BSEP staining (courtesy of Imactiv 3D, Toulouse)

Expression of detoxification enzymes

A model for DMPK and for acute and chronic hepatotoxicity studies

For all our Human products, we ensure the following features:

  • Male or Female donor(s) with full traceability


  • Available as single or pooled donors


  • 45 days of viability post encapsulation


  • 180 cells per HepatoPearls®


  • Delivery in bulk or in plates of your choice (from 24 to 96-well plates)


  • From 1 to hundreds of HepatoPearls® per well according to your needs and the requested plates


  • Delivery at physiological temperature (37°C / 98.6°F) in Europe and in the USA*
    * Please contact us for any other territories